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Engineered Liposomes for Potential -Particle Therapy of Metastatic Cancer

¹ Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York
² Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York
³ Department of Chemical Engineering, Columbia University, New York, New York
⁴ Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medicine, Baltimore, Maryland

View larger version (20K): [in a new window]   FIGURE 1. Simplified 225Ac decay cascade with associated particulate decays and half-lives.

View larger version (76K): [in a new window]   FIGURE 2. Negative-staining transmission electron microscopy images of liposomes prepared with 800-nm (A) and 100-nm (B) filter diameter.

View larger version (13K): [in a new window]   FIGURE 3. Fraction of 225Ac retention by zwitterionic liposomes (filter diameters: 100 (•), 400 (), and 800 () nm) during 30 d. The error bars correspond to SEs of repeated measurements.

View larger version (14K): [in a new window]   FIGURE 4. Fraction of 225Ac retention by cationic liposomes (filter diameters: 100 (•), 400 (), and 800 () nm) during 30 d. The error bars correspond to SEs of repeated measurements.

View larger version (17K): [in a new window]   FIGURE 5. Theoretical predictions of 213Bi retention for different liposome sizes (solid line). Radionuclides were assumed to be uniformly entrapped into the liposomal aqueous compartment. The average recoil distance of 87.6 nm was used for all -emitting intermediates to simplify calculations. Binding of radionuclides to the liposomal membrane will significantly reduce retention (dotted line).

View larger version (14K): [in a new window]   FIGURE 6. Fraction of 213Bi retention by zwitterionic liposomes (filter diameters: 100 (•), 400 () and 800 () nm) during 30 d. The error bars correspond to SEs of repeated measurements (for some data points, error bars are smaller than the symbol sizes). For day 30, 213Bi retention for 100- and 400-nm liposomes is 0%, and data points overlap. 213Bi retention in 800-nm liposomes was significantly higher than that in 100-nm liposomes (P = 0.0044).

View larger version (13K): [in a new window]   FIGURE 7. Fraction of 213Bi retention by cationic liposomes (filter diameters: 100 (•), 400 () and 800 () nm) during 30 d. The error bars correspond to SEs of repeated measurements (for some data points, error bars are smaller than the symbol sizes). For days 20 and 30, 213Bi retention for 100- and 400-nm liposomes is 0%, and data points overlap.