Impact of Radioimmunoscintigraphy on Definition of Clinical Target Volume for Radiotherapy After Prostatectomy
Ashesh B. Jani, MD1,
Danny Spelbring, PhD1,
Russell Hamilton, PhD2,
Michael J. Blend, PhD, DO3,
Charles Pelizzari, PhD1,
Charles Brendler, MD4,
Lani Krauz, RN1,
Srinivasan Vijayakumar, MD5,
Bipin Sapra, MTech1 and
Ralph R. Weichselbaum, MD1
1 Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois
2 Department of Radiation Oncology, University of Arizona, Tuczon, Arizona
3 Section of Nuclear Medicine, Department of Radiology, University of Illinois at Chicago, Chicago, Illinois
4 Section of Urology, Department of Surgery, University of Chicago, Chicago, Illinois
5 Department of Radiation Oncology, University of California at Davis, Sacramento, California
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FIGURE 1. Flow diagram of image data, showing how planning CT was registered with simultaneously acquired dual-isotope 99mTc-labeled RBC SPECT and 111In-mAb RIS scans, enabling the projection of CTVRIS into the planning CT scan for assistance in modifying CTVpre to define CTVpost.
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FIGURE 2. Axial images of planning CT showing the use of RIS in modifying the prostate-bed CTV. Normal structures: bladder (blue), and rectum (green). (A) The CTVpre (red) was entered before the RIS/CT fusion. CTVRIS (yellow) is the projection of the delineated uptake on the RIS scan into the planning CT. (B) CTVRIS was used to modify CTVpre to define CTVpost (aqua). In this case, CTVpost is the union of CTVpre and CTVRIS in A.
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FIGURE 3. Dose volume histogram dosimetric endpoints for bladder and rectum. AUC = hatched area.
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FIGURE 4. Kaplan–Meier curve displaying biochemical failure-free survival for the cohort.
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Copyright © 2004 by the Society of Nuclear Medicine.
