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Age-Dependent Variation of Follicular Size and Expression of Iodine Transporters in Human Thyroid Tissue

¹ Department of Nuclear Medicine, Commissariat à l’Energie Atomique, Institut Gustave Roussy, Villejuif, France
² Department of Physics, Commissariat à l’Energie Atomique, Institut Gustave Roussy, Villejuif, France
³ Department of Statistics, Commissariat à l’Energie Atomique, Institut Gustave Roussy, Villejuif, France
⁴ Department of Pathology, Commissariat à l’Energie Atomique, Institut Gustave Roussy, Villejuif, France
⁵ Department of Clinical Biology, Commissariat à l’Energie Atomique, Institut Gustave Roussy, Villejuif, France

View larger version (134K): [in a new window]   FIGURE 1. Paraffin-embedded human thyroid tissue stained with hematoxylin–eosin–safranin (original magnification, x142): morphologic aspect. The major axis of each follicle crossed by or tangent to the diagonal was measured.

View larger version (16K): [in a new window]   FIGURE 2. Distribution of follicular diameters according to age at surgery. Smaller follicles (<100 µm in diameter) are prevalent in patients 12 y old, and larger follicles (>200 µm in diameter), in older patients.

View larger version (117K): [in a new window]   FIGURE 3. Immunohistochemical expression of NIS in thyroid tissues according to age at surgery (original magnification, x100). (A) Strong staining is seen in the majority of follicles of an 8-y-old patient. In some smaller follicles, all thyrocytes are stained. (B) Strong staining is seen in a few small follicles of a 17-y-old patient; in positive follicles, only single or a few thyrocytes are stained.

View larger version (19K): [in a new window]   FIGURE 4. Age distribution of thyroid cell proliferation rate, as estimated by the number of cyclin A–positive thyrocytes per 10 high-power fields.