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Reproducibility of 99mTc-TRODAT-1 SPECT Measurement of Dopamine Transporters in Parkinson’s Disease

Wen J. Hwang, MD1, Wei J. Yao, MD2, Shiaw P. Wey, PhD3 and Gann Ting, PhD4

1 Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
2 Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
3 Division of Radiological Technology, School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
4 Institute of Nuclear Energy Research, Lung-Tan, Taiwan



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FIGURE 1. Agreement between the test and retest conditions for measuring the mean ratio of specific-striatal-to-nonspecific uptake ([striatum - occipital cortex]/occipital cortex). The line of identity (Y = X) emerging from the origin (0,0) indicates complete agreement between the 2 conditions. The dashed lines represent 95% confidence curves. The 95% CI for the observed correlation of 0.91 is 0.78–0.97.

 


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FIGURE 2. Ratio of specific-striatal-to-nonspecific uptake. Solid line shows the mean difference score (0.00). The 95% limits of agreement represent 2 SDs above and below the mean difference score ( ± 2 SDs = 0.00 ± 0.19 = -0.19 to 0.19).

 


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FIGURE 3. Agreement between the test and retest conditions for measuring the striatal AI. The line of identity (Y = X) emerging from the origin (0,0) indicates complete agreement between the 2 conditions. The dashed lines represent 95% confidence curves. The 95% CI for the observed correlation of 0.76 is 0.48–0.90.

 


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FIGURE 4. Striatal AI. Solid line shows the mean difference score (-0.44). The 95% limits of agreement represent 2 SDs above and below the mean difference score ( ± 2 SDs = -0.44 ± 15.63 = -16.09 to 15.19).

 


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FIGURE 5. The correlation between UPDRS motor subscore and the mean ratio of specific-striatal-to-nonspecific uptake ([ST - OC]/OC) of the test and retest conditions. The dashed lines represent 95% confidence curves. The 95% CI for the observed correlation of -0.53 is -0.05 to -0.79 (test condition) and that for the observed correlation of -0.48 is -0.05 to -0.76 (retest condition).

 





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