Prediction of Survival and Therapy Outcome with 11C-Tyrosine PET in Patients with Laryngeal Carcinoma
Jurjan R. de Boer, MD1,
Jan Pruim, MD, PhD2,
Frans W.J. Albers, MD, PhD1,
Fred Burlage, MD3,
Willem Vaalburg, PhD2 and
Bernard F.A.M. van der Laan, MD, PhD1
1 Department of Otorhinolaryngology and Head and Neck Surgery, Groningen University Hospital, Groningen, The Netherlands
2 PET Center of Groningen University Hospital, Groningen, The Netherlands
3 Department of Radiotherapy, Groningen University Hospital, Groningen, The Netherlands

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FIGURE 1. Transaxial CT and 11C-TYR PET scans of patient 28, with T3 N0 supraglottic squamous cell carcinoma (1), show increased 11C-TYR uptake in tumor.
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FIGURE 2. Cumulative survival of patients with T1T4 laryngeal carcinomas (n = 34). Differences between patients with tumor PSR equal to or higher than the median (2.0 nmol/mL/min) and patients with tumor PSR lower than the median are demonstrated (P = 0.07).
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FIGURE 3. Survival curves (Kaplan-Meier) for patients with laryngeal carcinomas treated with primary radiotherapy (n = 20). Significant differences (P = 0.03) are demonstrated between patients (n = 9) with tumor PSR equal to or higher than the median (2.0 nmol/mL/min) and patients (n = 11) with tumor PSR lower than the median.
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Copyright © 2004 by the Society of Nuclear Medicine.