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Kinetic Analysis of 18F-Fluorodihydrorotenone as a Deposited Myocardial Flow Tracer: Comparison to 201Tl

Robert C. Marshall, MD, Patricia Powers-Risius, BA, Bryan W. Reutter, MS, James P. O’Neil, PhD, Michael La Belle, PhD, Ronald H. Huesman, PhD and Henry F. VanBrocklin, PhD

Department of Nuclear Medicine and Functional Imaging, E.O. Lawrence Berkeley National Laboratory, University of California, Berkeley, California



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  		FIGURE 1. (A) Fractional venous appearance rate, h(t), for 18F-FDHR, 201Tl, and 131I-albumin as a function of venous collection times. (B) Delayed components of the deconvolved impulse response function, i(t), for the first 120 s. Both datasets are from the same experiment; the coronary flow rate was 1.6 mL/min/g of LV wet weight.

 


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  		FIGURE 2. Initial extraction fractions, D0, for 18F-FDHR and 201Tl as a function of blood flow. Data were pooled from 22 experiments; each data point represents a single experiment. Equations for the linear fits to the data points are shown.

 


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  		FIGURE 3. FER(t) as a function of flow and time for 18F-FDHR (A and C) and 201Tl (B and D) during the first 30 s (A and B) and from 30 s to 15 min (C and D).

 


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  		FIGURE 4. Enet(t) as a function of flow and time for 18F-FDHR (A) and 201Tl (B).

 


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  		FIGURE 5. Net uptake, U(t), as a function of flow and time for 18F-FDHR (A) and 201Tl (B).

 


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  		FIGURE 6. Relationship between net uptake, U(t), and flow for 18F-FDHR and 201Tl (A and C) and 125I-iodorotenone and 99mTc-sestamibi (B and D) at 1 min (A and B) and 15 min (C and D).

 


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  		SCHEME 1. Production of 18F-FDHR from DHR-ol-OTs.

 




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