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18F-FDG Kinetics in Locally Advanced Breast Cancer: Correlation with Tumor Blood Flow and Changes in Response to Neoadjuvant Chemotherapy

Jeffrey Tseng, MD, Lisa K. Dunnwald, BS, Erin K. Schubert, BA, Jeanne M. Link, PhD, Satoshi Minoshima, MD, PhD, Mark Muzi, MS and David A. Mankoff, MD, PhD

Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington



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FIGURE 1. Arrows show direction of changes in mean blood flow and Ki values before -> after chemotherapy. Ki decreased for all response groups. Blood flow decreased for mCR and PR groups; however, it increased for NR group. Error bars represent SEM.

 


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FIGURE 2. Correlation between blood flow and Ki before chemotherapy for all patients revealed 1 far outlier.

 


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FIGURE 3. Correlations between blood flow and Ki or K1 before and after chemotherapy excluding 1 far outlier. (A) Blood flow and Ki before chemotherapy. (B) Blood flow and Ki after chemotherapy. (C) Blood flow and K1 before chemotherapy. (D) Blood flow and K1 after chemotherapy. Correlation between blood flow and Ki improved after chemotherapy.

 





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