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Tissue-Specific Effects on Uptake of ^99mTc-Sestamibi by Breast Lesions: A Targeted Analysis of False Scintigraphic Diagnoses

¹ Department of Nuclear Medicine, Innenstadt Ludwig-Maximilians-University of Munich, Munich, Germany
² Department of Gynecology and Obstetrics, Innenstadt Ludwig-Maximilians-University of Munich, Munich, Germany

View larger version (16K): [in a new window]   FIGURE 1. Sestamibi uptake by breast lesions in relation to tumor size.

View larger version (16K): [in a new window]   FIGURE 2. Sestamibi uptake by breast lesions in relation to cellular density.

View larger version (145K): [in a new window]   FIGURE 3. Ductal invasive carcinoma with a low cellular density. (A) HE-stained section shows a low proportion of carcinoma cells, compared with the surrounding connective tissue. (B) Scintimammography findings are false-negative, showing a normal and homogeneous distribution of the radiopharmaceutical.

View larger version (149K): [in a new window]   FIGURE 4. Ductal invasive carcinoma with a high cellular density. (A) HE-stained section shows a high proportion of carcinoma cells, compared with the surrounding connective tissue. (B) At scintigraphy, the carcinoma exhibited marked focal 99mTc-sestambi uptake.

View larger version (15K): [in a new window]   FIGURE 5. Sestamibi uptake by breast lesions in relation to vascularity.

View larger version (16K): [in a new window]   FIGURE 6. Sestamibi uptake by breast lesions in relation to inflammatory changes.

View larger version (147K): [in a new window]   FIGURE 7. Chronic mastitis. (A) HE-stained section shows pronounced inflammatory components in the area of the milk ducts and surrounding connective tissue. (B) Scintimammography reveals significantly increased 99mTc-sestambi uptake, which is characteristic of malignancy.