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Loss of Dopamine Transporter Binding in Parkinson’s Disease Follows a Single Exponential Rather Than Linear Decline

¹ Department of Neurology, University of Leipzig, Leipzig, Germany
² Department of Neurology, University of Ulm, Ulm, Germany
³ Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich, Germany
⁴ Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany
⁵ Imaging Research, Sunnybrook and Women’s College Health Sciences Centre, Toronto, Ontario, Canada

View larger version (19K): [in a new window]   FIGURE 1. In patients with PD, data on 7.5-y follow-up of striatal DAT binding. Data are best fitted by a single exponential decay (solid line). Extrapolation of calculated single exponential decline hits control values 4–5 y before the first scan (dashed line). The 3 initial patient scans are well fitted by a linear decline (dotted line).