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Imaging of Experimental Colitis with a Radiolabeled Leukotriene B4 Antagonist

Julliëtte E.M. van Eerd, BSc1, Peter Laverman, PhD1, Wim J.G. Oyen, MD, PhD1, Thomas D. Harris, PhD2, D. Scott Edwards, PhD2, Charles E. Ellars, MSc2, Frans H.M. Corstens, MD, PhD1 and Otto C. Boerman, PhD1

1 Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
2 Discovery Research, Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts



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  		FIGURE 1. Anterior scintigraphic images of rabbits that were placed prone on {gamma}-camera. (A) Images acquired 0, 1, 2, and 3 h after injection of 18.5 MBq 99mTc-granulocytes in rabbit with acute colitis. (B) Images acquired 0, 1, 2, 4, and 6 h after injection of 11 MBq 111In-DPC11870 in rabbit with acute colitis. (C) 3-Dimensional representation of image acquired 1 h after injection of 30 MBq 18F-FDG in rabbit with acute colitis. (D) Images acquired 0, 1, 2, 4, and 6 h after injection of 11 MBq 111In-DPC11870 in healthy rabbit.

 


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  		FIGURE 2. Biodistribution data of rabbits that received intravenous injections of 111In-DPC11870, 99mTc-granulocytes, or 18F-FDG. Uptake in organs and tissues is expressed as %ID/g. Each bar represents mean ± SD. Ex vivo biodistribution was determined 6 h after injection for 111In-DPC11870, 3 h after injection for 99mTc-granulocytes, and 1 h after injection for 18F-FDG.

 


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  		FIGURE 3. Mean ratios of affected colon to unaffected colon for 18F-FDG, 99mTc-granulocytes, and 111In-DPC11870 at 1, 3, and 6 h after injection, respectively. Ratios were derived from individual colonic segments taken at dissection.

 


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  		FIGURE 4. Amount of activity (%ID) found in colonic wall and in content of affected colon for the 3 radiopharmaceuticals: 111In-DPC11870, 99mTc-granulocytes, and 18F-FDG.

 




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