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Characterization of the Generation of Radiolabeled Monodisperse Albuterol Particles Using the Spinning-Top Aerosol Generator

¹ Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
² Department of Nuclear Medicine, Royal Brompton Hospital, London, United Kingdom

View larger version (29K): [in a new window]   FIGURE 1. Simplified schematic diagram showing principle of operation of aerosol generation and delivery system, incorporating STAG disk, inhalation control unit, inhalation chamber, and position of aerodynamic particle sizer or patient.

View larger version (14K): [in a new window]   FIGURE 2. Mean percentage deposition of radiolabel, labeled albuterol, and unlabeled albuterol for aerosols with MMADs of 1.5 µm (A), 3 µm (B), and 6 µm (C), collected on the 9 stages of an Andersen cascade impactor operated at flow rate of 28.3 L/min. Effective cutoff diameters (e.c.d.) for the 8 impactor stages and backup filter are shown. Data are of 3 experiments, and error bars indicate SD of each value.

View larger version (37K): [in a new window]   FIGURE 3. Posterior thorax (A), anterior thorax (B), and lateral throat (C) -camera images of asthmatic patient using 99mTc-labeled aerosol particles with MMAD of 3 µm (GSD, 1.18). Red areas indicate regions of highest radioactivity, and black, of least.

View larger version (13K): [in a new window]   FIGURE 4. Clearance of 99mTc from lungs of asthmatic patient. Data at each 1-min image are shown as percentage of initial radioactivity counts for anterior and posterior images. This was calculated by dividing total acquired lung counts in each image by those obtained from first 1-min image.