99mTc-TRODAT-1 Imaging of Multiple System Atrophy
Chin-Song Lu, MD1,
Yi-Hsin Weng, MD1,
Min-Chi Chen, PhD2,
Rou-Shayn Chen, MD1,
Kai-Yuan Tzen, MD3,
Shiaw-Pyng Wey, PhD4,
Gann Ting, PhD4,
Hsiu-Chen Chang, BS1 and
Tzu-Chen Yen, MD, PhD3
1 First Department of Neurology, Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan
2 Biostatistics Center/Department of Public Health, Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan
3 Department of Nuclear Medicine, Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan; and Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan
4 Chang Gung Memorial Hospital at Lin-Ko and Taoyuan, Chang Gung University, Institute of Nuclear Energy Research, Lung-Tan, Taiwan
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FIGURE 1. 99mTc-TRODAT-1 SPECT images of 4 similarly aged individuals, 1 from each group: healthy subject (A), MSA-C patient (B), MSA-P patient (C), and PD control patient (D).
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FIGURE 2. Bilateral putaminal uptakes (P/O ratios) of 99mTc-TRODAT-1 in 4 groups. Bilateral P/O ratios are significantly reduced in PD and MSA-P groups but are less reduced in MSA-C group. Cont = contralateral; Ipsi = ipsilateral.
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FIGURE 3. Bilateral caudate nucleus uptakes (C/O ratios) of 99mTc-TRODAT-1 in 4 groups. Similar to findings for P/O ratios, bilateral C/O ratios are significantly reduced in PD and MSA-P groups but are only mildly reduced in MSA-C group. Cont = contralateral; Ipsi = ipsilateral.
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FIGURE 4. Bilateral P/C ratios of 99mTc-TRODAT-1 in 4 groups. There is preferential involvement of putamen in PD and MSA-P groups, whereas P/C ratios for MSA-C are closer to those of healthy subjects. This indicates relatively diffuse involvement of both putamen and caudate nucleus in MSA-C group. Cont = contralateral; Ipsi = ipsilateral.
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Copyright © 2004 by the Society of Nuclear Medicine.
