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Analysis of the Regional Uptake of Radiolabeled Deoxyglucose Analogs in Human Tumor Xenografts

¹ Cancer Research UK Targeting and Imaging Group, Academic Department of Oncology, Royal Free and University College Medical School, Royal Free Campus, University College London, Hampstead, London, United Kingdom
² The Clinical PET Centre, Guy’s, King’s and St. Thomas’ Hospital, London, United Kingdom
³ Department of Biomedical Engineering, University of California, Davis, California

View larger version (75K): [in a new window]   FIGURE 1. Typical images show histology and corresponding radioluminographs show radionuclide distribution within tumor sections. H&E demonstrates general morphology (top), staining viable regions (V) darker than necrotic regions (N). Hypoxia was demonstrated using immunohistochemical method to detect 2-nitroimidazole metabolites (bottom). Bar = 2.0 mm. High-resolution image shows detail from 18F-FDG image.

View larger version (49K): [in a new window]   FIGURE 2. Graphs show relative distribution of radiotracers within major pathophysiologic compartments of tumor. (A) Comparison of mean counts per pixel from 18F-FDG and 14C-2DG in viable and necrotic regions. (B) Comparison of mean counts per pixel in hypoxic and normoxic regions, throughout time course described (n = 4 for each time point; error bars are 1 SD about mean).

View larger version (46K): [in a new window]   FIGURE 3. Graphs show background (Bg), minimum (Min), mean, and maximum (Max) counts in viable and necrotic (A) and in hypoxic and normoxic (B) regions of tumor. For sake of comparison, datasets were normalized so that mean viable and mean hypoxic values on y-axis are 100 (n = 4 for each time point; error bars are 1 SD about mean).

View larger version (29K): [in a new window]   FIGURE 4. Graphs show count frequency in viable and necrotic regions and in hypoxic and normoxic regions of tumors from 18F-FDG (A) and 14C-2DG (B) at 30 min. Counts on x-axis are actual counts recorded.