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Comparative Biodistribution of Iodinated Amino Acids in Rats: Selection of the Optimal Analog for Oncologic Imaging Outside the Brain

Tony Lahoutte, MD, John Mertens, PhD, Vicky Caveliers, PharmD, PhD, Philippe R. Franken, MD, PhD, Hendrik Everaert, MD, PhD and Axel Bossuyt, MD, PhD

Department of Nuclear Medicine, Academic Hospital, Free University Brussels, Jette, Belgium



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  		FIGURE 1. Chemical structures of iodinated amino acid analogs under investigation.

 


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  		FIGURE 2. Summed images (30–40 min after injection) from dynamic planar imaging study. Images are scaled to maximum in tumor.

 


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  		FIGURE 3. 18F-FDG and 123I-2-IT images from R1M tumor-bearing rat with coexisting inflammation (summed images at 30–40 min after injection).

 


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  		FIGURE 4. Ratio of tracer uptake in inflamed tissue to that in noninflamed tissue as function of time for 18F-FDG (+) and 123I-3-IMT (•) (A) and for 18F-FDG (+) and 123I-2-IT ({blacksquare}) (B).

 




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