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Uptake-1 Carrier Downregulates in Parallel with the ß-Adrenergic Receptor Desensitization in Rat Hearts Chronically Exposed to High Levels of Circulating Norepinephrine: Implications for Cardiac Neuroimaging in Human Cardiomyopathies

Karine Mardon, PhD1, Olivier Montagne, MD1,2, Nathalie Elbaz, MD3, Zoulikha Malek, MD4, André Syrota, MD, PhD1, Jean-Luc Dubois-Randé, MD, PhD2,3, Michel Meignan, MD4 and Pascal Merlet, MD, PhD2,4

1 Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, Direction des Sciences du Vivant-Commissariat à l’Energie Atomique, Orsay, France
2 Institut National pour la Santé et la Recherche Médicale, Unité 400, Université de Médecine, Créteil, France
3 Fédération de Cardiologie, Centre Hospitalo-Universitaire Henri Mondor-Université Paris XII, Créteil, France
4 Service de Médecine Nucléaire, Centre Hospitalo-Universitaire Henri Mondor-Université Paris XII, Créteil, France



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  		FIGURE 1. Effect of chronic infusion of NE on myocardial noradrenergic neurotransmission. After 5-d NE infusion, similar reduction in NE uptake, uptake-1 carrier density, ß-adrenergic receptor (BAR) density, and responsiveness to agonists was observed in left ventricle of rats. ACA = adenylyl cyclase activity; Bmax = carrier or receptor protein density. *P < 0.05. **P < 0.01. ***P < 0.001.

 




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