Does Asymmetric Basal Ganglia or Thalamic Activation Aid in Seizure Foci Lateralization on Ictal SPECT Studies?
Jitka Sojkova, MD1,
Petra J. Lewis, MBBS2,
Alan H. Siegel, MD2,
Adrian M. Siegel, MD3,
David W. Roberts, MD4,
Vijay M. Thadani, MD3 and
Peter D. Williamson, MD3
1 Dartmouth Medical School, Hanover, New Hampshire
2 Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
3 Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
4 Department of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

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FIGURE 1. Example of ipsilateral basal ganglia lateralization. Asymmetric basal ganglia activation (left > right) in patient with left frontal focus (not visualized here) seen on transaxial ictal and subtraction SPECT images. Arrows indicate activation of left caudate.
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FIGURE 2. Example of ipsilateral thalamic lateralization. Asymmetric thalamus activation (right > left) in patient with right mesiotemporal focus seen on coronal ictal and subtraction SPECT images. Arrow indicates right thalamic activation.
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FIGURE 3. Example of contralateral basal ganglia activation. Transaxial SPECT images of patient with final focus in right temporal neocortex focus (not shown), who was found to have left basal ganglia uptake (solid arrow), right thalamic uptake (dashed arrow), and increased uptake in left temporal neocortex in study with injection time of 8 s.
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FIGURE 4. Example of contralateral thalamic activation. Transaxial SPECT images show left thalamic (dashed arrow) and basal ganglia (solid arrow) activation. Left cortical activation observed in this study (presumably due to generalization of seizure) is not visualized. Patients final focus was located in right temporal lobe.
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Copyright © 2003 by the Society of Nuclear Medicine.