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Differences in Vasodilatory Capacity and Changes in Cerebral Blood Flow Induced by Acetazolamide in Patients with Cerebrovascular Disease

¹ PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
² Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan

View larger version (33K): [in a new window]   FIGURE 1. Bilateral changes in rCBF and V0 in cortical territories of MCA before and after ACZ administration. Increase in rCBF and V0 for all patients was significant when before-ACZ administration was compared with after-ACZ administration, although 4 of 16 patients showed reduction in rCBF in ipsilateral hemisphere. V0 in all 4 patients increased on same side of hemisphere. Changes in patients of group A (•) are represented by dashed lines, and solid lines show changes in group B (x).

View larger version (59K): [in a new window]   FIGURE 2. Representative images of patients with occlusion of right ICA in group A: patient with normal OEF values in bilateral hemispheres (A) and patient with significantly greater OEF in ipsilateral hemisphere (B). Interhemispheric difference in rCBF was intensified and absolute rCBF values decreased on ipsilateral side, although V0 was slightly increased in same region. Corresponding OEF images show asymmetric increase in ipsilateral hemisphere in both patients. Same color scale is used for same parametric images.

View larger version (15K): [in a new window]   FIGURE 3. Relationship between OEF and percentage change in rCBF induced by ACZ administration. (A) Absolute OEF values and percentage change in rCBF showed no relationship in either ipsilateral (•) or contralateral () hemisphere. (B) Asymmetry index for OEF was linearly correlated only in ipsilateral hemisphere. Line is regression line for correlation in ipsilateral hemisphere (r = 0.64; P < 0.05).