HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hofland, L. J. Articles by Breeman, W. A.P. Search for Related Content PubMed PubMed Citation Articles by Hofland, L. J. Articles by Breeman, W. A.P.

Crucial Role for Somatostatin Receptor Subtype 2 in Determining the Uptake of [¹¹¹In-DTPA-D-Phe¹]Octreotide in Somatostatin Receptor–Positive Organs

¹ Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
² Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland
³ Merck Laboratories, New York, New York
⁴ Mallinckrodt Discovery, St. Louis, Missouri
⁵ Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

View larger version (87K): [in a new window]   FIGURE 1. Expression of SS and sst1–5 mRNAs in different tissues of wild-type and sst2 knockout mice, as determined by RT-PCR. All mock-reverse-transcribed samples and all controls with no added template showed no PCR products. Marker lanes (M) contain 100-bp DNA ladder. H = hprt; Mw = molecular weight.

View larger version (21K): [in a new window]   FIGURE 2. Uptake values of radioactivity after injection of [111In-DTPA-D-Phe1]octreotide (A) and [111In-DTPA]SS-14 (B), expressed as percentage injected dose per gram of tissue (% ID/gram) in pituitary gland, adrenals, pancreas, and thymus of wild-type mice (white bars) and sst2 knockout mice (black bars) (n = 4).