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Mediastinal Lymph Node Involvement in Non–Small Cell Lung Cancer: Evaluation with ^99mTc-Tetrofosmin SPECT and Comparison with CT

¹ Department of Diagnostic Imaging, University of Rome "Tor Vergata," Rome, Italy
² Department of Nuclear Medicine, University of Sassari, Sassari, Italy
³ Department of Radiologic Sciences, University of Rome "La Sapienza," Rome, Italy
⁴ Department of Surgery, University of Rome "La Sapienza," Rome, Italy
⁵ Department of Respiratory Diseases, University of Sassari, Sassari, Italy

View larger version (109K): [in a new window]   FIGURE 1. A 77-y-old man with adenocarcinoma of right upper lobe. (A) CT scan shows primary tumor (double arrow) and enlarged paratracheal lymph nodes (single arrows). (B) 99mTc-Tetrofosmin SPECT in transaxial view demonstrates wide area of increased abnormal uptake corresponding to primary tumor (double arrow). Focal area of increased uptake corresponding to paratracheal metastatic lymph nodes (single arrow) was also observed in anterior upper right mediastinum.

View larger version (99K): [in a new window]   FIGURE 2. A 45-y-old woman with epidermoid squamous cell carcinoma of left upper lobe. (A) CT scan shows primary tumor (double arrow) and enlarged paraaortic lymph nodes (single arrow). (B) 99mTc-Tetrofosmin SPECT in transaxial view demonstrates area of increased abnormal uptake corresponding to primary tumor (double arrow) but no accumulation in mediastinum. Metastases were excluded at histology in dissected mediastinal nodes positive at CT.