Crossover Study of 99mTc-TRODAT-1 SPECT and 18F-FDOPA PET in Parkinson’s Disease Patients
Wen-Sheng Huang, MD1,
Yung-Hsiao Chiang, MD, PhD2,
Jiann-Chyun Lin, MD, PhD3,
Yuan-Hwa Chou, MD, PhD4,
Cheng-Yi Cheng, MD, PhD1 and
Ren-Shyan Liu, MD5
1 Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan
2 Department of Neurological Surgery, Tri-Service General Hospital, Taipei, Taiwan
3 Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan
4 Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan
5 Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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FIGURE 1. Representative transverse 99mTc-TRODAT-1 SPECT images (A) and concordant 18F-FDOPA PET images (B) of healthy volunteer. Bilateral, symmetrically normal uptake in striatum is seen on both SPECT and PET.
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FIGURE 2. Representative transverse 99mTc-TRODAT-1 SPECT images (A) and concordant 18F-FDOPA PET images (B) of patient with HYS II PD (patient 16). Markedly decreased uptake in right putamen, with less apparent decrease in left putamen, was found on both SPECT and PET.
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FIGURE 3. Transverse 99mTc-TRODAT-1 SPECT images (A) and discordant 18F-FDOPA PET images (B) of patient with HYS I PD (patient 1). SPECT images showed greater loss of uptake in left putamen and appeared more correlated with clinical manifestations than did corresponding 18F-FDOPA PET images.
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FIGURE 4. Transverse 99mTc-TRODAT-1 SPECT images (A) and discordant 18F-FDOPA PET images (B) of patient with HYS II PD (patient 15). PET images correlated better with clinical staging than did corresponding 99mTc-TRODAT-1 SPECT images, which appeared to overestimate disease severity.
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Copyright © 2003 by the Society of Nuclear Medicine.
= HYS I; 
= HYS II; 
= HYS III; • = HYS IV.