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Characteristic Brain Distribution of 1-¹⁴C-Octanoate in a Rat Model of Focal Cerebral Ischemia in Comparison with Those of ¹²³I-IMP and ¹²³I-Iomazenil

¹ Departments of Tracer Kinetics and Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
² Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari, Japan

View larger version (63K): [in a new window]   FIGURE 1. (A) Example of ROIs placed 2–4, 6–8, and 10–12 mm caudal from frontal pole on 3 coronal images. (B) Representative images of HE stain (x200). (C) Example of classified ROIs determined on images of HE stain. Black circle = region A; green circle = region B; blue circle = region C. (D) Approximate relationship of ROI classification with TTC stain. Black circle = region A; green circle = region B; blue circle = region C.

View larger version (62K): [in a new window]   FIGURE 2. Representative images of TTC staining and autoradiograms for 123I-IMP and 1-14C-octanoate at 4 (A) and 24 (B) h after insult. 1-14C-Octanoate uptake decreased in infarct regions (TTC-unstained region), indicated by red arrows, but was relatively preserved in periinfarct regions with reduced 123I-IMP uptake, indicated by black arrows.

View larger version (48K): [in a new window]   FIGURE 3. (A and B) Scattergrams and Bland-Altman plots between AIs for 123I-IMP and AIs for 1-14C-octanoate 4 (A) and 24 (B) h after insult. • = region A; = region B; = region C1IMP; = region C2IMP, AIIMP = AI for 123I-IMP; AIOA = AI for 1-14C-octanoate; regions A, B, C1IMP, and C2IMP are classified in Table 1. (C and D) AIs for 123I-IMP and 1-14C-octanoate in each region at 4 (C) and 24 (D) h after insult. Hatched bars = 123I-IMP; solid bars = 1-14C-octanoate. *P < 0.0125 vs. 123I-IMP. **P < 0.0001 vs. 123I-IMP.

View larger version (54K): [in a new window]   FIGURE 4. Representative images of TTC staining and autoradiograms for 123I-IMZ and 1-14C-octanoate at 4 (A) and 24 (B) h after insult. 1-14C-Octanoate uptake decreased in infarct regions (TTC-unstained region), indicated by red arrows, but was relatively preserved in peri-infarct regions with reduced 123I-IMZ uptake, indicated by black arrows.

View larger version (49K): [in a new window]   FIGURE 5. (A and B) Scattergrams and Bland-Altman plots between AIs for 123I-IMZ and AIs for 1-14C-octanoate at 4 (A) and 24 (B) h after insult. • = region A; = region B; = region C1IMZ; = region C2IMZ, AIIMZ = AI for 123I-IMZ; AIOA = AI for 1-14C-octanoate; regions A, B, C1IMZ, and C2IMZ are classified in Table 1. (C and D) AIs for 123I-IMZ and 1-14C-octanoate in each region at 4 (C) and 24 (D) h after insult. Hatched bars = 123I-IMZ; solid bars = 1-14C-octanoate. *P < 0.0125 vs. 123I-IMZ. **P < 0.0001 vs. 123I-IMZ.

View larger version (20K): [in a new window]   FIGURE 6. Schematic representation of possible relationship between tracer accumulation and cerebral function. I = preserved neuronal and astroglial function; II = impaired neuronal function and preserved astroglial function; III = impaired neuronal and astroglial function.