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Validation of Gastric-Emptying Scintigraphy of Solids and Liquids in Mice Using Dedicated Animal Pinhole Scintigraphy

Roelof J. Bennink, MD1, Wouter J. de Jonge, PhD2, Erin L. Symonds, PhD3, Rene M. van den Wijngaard, PhD2, Astrid L. Spijkerboer1, Marc A. Benninga, MD, PhD2 and Guy E. Boeckxstaens, MD, PhD2

1 Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
2 Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
3 Gastroenterology Unit, Women’s and Children’s Hospital, Adelaide, South Australia, Australia



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  		FIGURE 1. Routine pinhole collimator fitted with custom-made plastic adaptor. Using dorsal skin grasp and immobilization against adaptor makes high-quality imaging possible without need for sedation and with standardization of distance and orientation toward pinhole aperture.

 


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  		FIGURE 2. Representative images of gastric emptying in control mouse immediately after solid test meal (A) and every 15 min thereafter up to 60 min (B–E). ROIs are drawn on every acquisition around total field of view (1), stomach (2), and background (3). (F) Gastric-emptying curve derived from measured time points enables assessment of gastric-emptying characteristics and calculation of T1/2.

 


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  		FIGURE 3. (A) Gastric-emptying curves of liquid test meal labeled with phenol red and 99mTc-albumin colloid. Gastric emptying measured with phenol red photospectrometry (liquid phenol red) did not significantly differ from gastric emptying measured with pinhole scintigraphy (liquid scintigraphy). (B) Individual time-point measurements of gastric phenol red recovery and gastric retention measured with pinhole scintigraphy. Correlation between methods was good (R = 0.96; r = 0.86; P < 0.001).

 


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  		FIGURE 4. Gastric-emptying curves of solid and liquid test meals (mean ± SD). Solid gastric emptying was significantly slower than liquid emptying (P < 0.01).

 




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