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Effects of Increased Lipid Concentration and Hyperemic Blood Flow on the Intrinsic Myocardial Washout Kinetics of ^99mTcN-NOET

Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia

View larger version (22K): [in a new window]   FIGURE 1. Initial 99mTcN-NOET myocardial uptake after bolus injection in isolated rat hearts perfused with KH buffer (control; n = 6), KH with FA-free BSA 0.03% (n = 5), or BSA 0.03% (n = 4). Myocardial 99mTcN-NOET uptake was reduced in presence of BSA and reduction was not dependent on degree of lipid loading.

View larger version (34K): [in a new window]   FIGURE 2. (A) Time course of 99mTcN-NOET myocardial activity after bolus injection in isolated perfused rat hearts. Hearts were perfused with KH buffer (control; n = 6), KH with FA-free BSA 0.03% (n = 5), or BSA 0.03% (n = 4). (B) t1/2 of 99mTcN-NOET myocardial washout from isolated perfused rat hearts. t1/2 values were determined by applying exponential fit (y = a0 x exp[-x/a1]) to individual 99mTcN-NOET myocardial washout curves in presence of FA-free BSA or BSA. Data are mean ± SEM of 5 and 4 experiments, respectively. *P < 0.05 vs. FA-free BSA.

View larger version (30K): [in a new window]   FIGURE 3. Time course of 99mTcN-NOET intrinsic myocardial washout from canine myocardium before (control) and after intravenous administration of intralipids (hyperlipidemia). Data are mean ± SEM of 3 experiments.

View larger version (22K): [in a new window]   FIGURE 4. Ultrasonic coronary blood flow and t1/2 of 99mTcN-NOET intrinsic myocardial washout from canine myocardium before (control) and after intravenous administration of intralipids (hyperlipidemia). t1/2 values were determined by applying exponential fit (y = a0 x exp[-x/a1]) to individual 99mTcN-NOET intrinsic myocardial washout curves. Data are mean ± SEM of 3 experiments. *P < 0.05 vs. preintralipids administration.

View larger version (24K): [in a new window]   FIGURE 5. Time course of 99mTcN-NOET intrinsic myocardial washout from canine myocardium after intracoronary bolus injection at rest (normal flow) and during vasodilator stress induced by adenosine A2A receptor agonist ATL-146e (0.3 µg/kg/min) (hyperemic flow). Data are mean ± SEM of 6 experiments.

View larger version (25K): [in a new window]   FIGURE 6. Ultrasonic coronary blood flow and t1/2 of 99mTcN-NOET intrinsic myocardial washout from canine myocardium at rest (control) and during vasodilator stress (hyperemia). t1/2 values were determined by applying exponential fit (y = a0 x exp[-x/a1]) to individual 99mTcN-NOET intrinsic myocardial washout curves. Data are mean ± SEM of 6 experiments. *P < 0.05 vs. control.