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SUV Varies with Time After Injection in ¹⁸F-FDG PET of Breast Cancer: Characterization and Method to Adjust for Time Differences

Division of Nuclear Medicine, University of Washington Medical Center, Seattle, Washington

View larger version (25K): [in a new window]   FIGURE 1. Tumor time–activity curves of VOIs for all patients: Sav (A) and Smax (B) vs. time.

View larger version (12K): [in a new window]   FIGURE 2. Example of linear fit for 2 lesions, one for which linear regression generated positive slope (A) and another for which linear regression generated negative slope (B).

View larger version (10K): [in a new window]   FIGURE 3. Rate of average Sav change vs. measured Sav at 57 min. SUV measurements were not corrected for plasma glucose concentrations.

View larger version (17K): [in a new window]   FIGURE 4. Rate of SUV change vs. SUV at single time point for different single uptake time points: glucose-corrected Sav (A) and glucose-corrected SUVmax (B). These plots can be used to compare SUV measured at different times between studies.

View larger version (21K): [in a new window]   FIGURE 5. Illustration of proposed SUV correction method where SUV increases linearly with time, and rate of change (dS/dt) at any fixed time increases linearly with SUV value (S) at that time (dashed lines). From any measured point, a desired point can be extrapolated by use of a predetermined reference point as given in Equations 3 and 5 and Table 1.

View larger version (13K): [in a new window]   FIGURE 6. Estimated Smax at 71–75 min after injection (using Eq. 3) compared with measured value at 71–75 min for 20 additional locally advanced breast cancer lesions in patients not included in original analysis.