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Verapamil Does Not Inhibit 99mTcN-NOET Uptake In Situ in Normal or Ischemic Canine Myocardium

Laurent M. Riou, PhD1, Catherine Ghezzi, PhD1, Gérald Vanzetto, MD, PhD1, Alexis Broisat, MS1, Jean-Paul Mathieu, PhD1, René Bontron1, Roberto Pasqualini, PhD2 and Daniel Fagret, MD, PhD1

1 Laboratoire d’Etude de Radiopharmaceutiques, University Hospital of Grenoble, Grenoble, France
2 Cis Bio International, Gif-sur-Yvette, France



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  		FIGURE 1. Experimental protocol. Verapamil and adenosine doses were 0.015 mg/kg/min x 10 min and 0.2 mg/kg/min, respectively. mic = injection of radioactive microspheres; LAD = left anterior descending coronary artery.

 


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  		FIGURE 2. Regional MBF and 99mTcN-NOET myocardial uptake in group 1 dogs with either adenosine or verapamil treatment. Raw and normalized 99mTcN-NOET uptake is expressed as cpm/[Bq/kg]/g and as cpm/[Bq/kg]/g normalized to MBF (in mL/min/g), respectively.

 


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  		FIGURE 3. Regional MBF and 99mTcN-NOET myocardial uptake in remote (A) and ischemic (B) zones of group 2 dogs with either adenosine or verapamil injections. Raw and normalized 99mTcN-NOET uptake is expressed as cpm/[Bq/kg]/g and as cpm/[Bq/kg]/g normalized to MBF (in mL/min/g), respectively.

 


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  		FIGURE 4. 99mTcN-NOET (A) and 201Tl uptake (B) plotted as function of MBF in myocardial segments from group 2 dogs with either adenosine or verapamil injection. Mean myocardial activities of 201Tl and 99mTcN-NOET and MBF are expressed as percentage of mean tracer activities and MBF from normal, nonischemic zone from each individual animal.

 




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