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Dosimetry of the Dopamine Transporter Radioligand 18F-FPCIT in Human Subjects

William Robeson, MA, Vijay Dhawan, PhD, Abdel Belakhlef, PhD, Yilong Ma, PhD, Von Pillai, BS, Thomas Chaly, PhD, Claude Margouleff, MS, David Bjelke, AAS and David Eidelberg, MD

Center for Neurosciences, North Shore University Hospital, Manhasset, New York



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  		FIGURE 1. Bladder time–activity curve for subject 7. Data points reflect actual radioactivity measured by PET scanner scaled by measured urine concentration at approximately 180 min. Data are then further normalized by injected radioactivity. Solid line is fit to experimental data using exponential uptake and elimination by voiding and physical decay.

 


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  		FIGURE 2. (A) Lung time–activity curve for subject 7. (B) Liver time–activity curve for subject 7.

 


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  		FIGURE 3. (A) Example of blood clearance curve for 18F-FPCIT. Solid curve represents total 18F in plasma. Dotted line is nonmetabolized 18F-FPCIT determined by high-pressure liquid chromatographic separation of blood samples. (B) Brain time–activity curve for subject 12.

 


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  		FIGURE 4. Uptake patterns of various organs as function of time for 18F-FPCIT. (A) Coronal image of 18F-FPCIT 0–6 min after injection shows early lung, spleen, and kidney uptake. (B) Coronal image of 18F-FPCIT 7–13 min after injection shows cardiac muscle uptake. (C) Coronal image of 18F-FPCIT 30–36 min after injection shows liver uptake and clearance from other organs. (D) Coronal image of 18F-FPCIT 112–122 min after injection shows persistent spinal uptake and liver clearance. (E) Transaxial section of urinary bladder acquired at 7 time points from 1 to 2 h after injection shows growth of activity in bladder before patient voiding.

 




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