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Reproducibility of ¹¹C-Raclopride Binding in the Rat Brain Measured with the MicroPET R4: Effects of Scatter Correction and Tracer Specific Activity

¹ Chemistry Department, Brookhaven National Laboratory, Upton, New York
² Medical Department, Brookhaven National Laboratory, Upton, New York
³ Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York
⁴ Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, Stony Brook, New York

View larger version (19K): [in a new window]   FIGURE 1. Typical sinogram projections in rat head with 11C-raclopride. (A) Ten minutes after injection. (B) Sixty minutes after injection.

View larger version (36K): [in a new window]   FIGURE 2. Test-retest experiments in rat brain with 11C-raclopride. For all graphs, circles represent striatum and diamonds represent cerebellum. %ID/cm3 = percentage of injected dose per cubic centimeter. • and , First injection; and , Second injection. (A) First injection, 12.84 MBq (347 µCi; 3.8 nmol/kg raclopride); second injection, 11.91 MBq (322 µCi; 1.9 nmol/kg raclopride). (B) First injection, 7.22 MBq (195 µCi; 1.2 nmol/kg raclopride); second injection, 6.51 MBq (176 µCi; 1.0 nmol/kg raclopride). (C) First injection, 5.99 MBq (162 µCi; 0.5 nmol/kg raclopride); second injection, 13.88 MBq (375 µCi; 1.7 nmol/kg raclopride). (D) Blocking study: first injection, 17.58 MBq (475 µCi; 15 nmol/kg raclopride); second injection, 18.54 MBq (501 µCi; 1 mg/kg or 2,881 nmol/kg raclopride).

View larger version (17K): [in a new window]   FIGURE 3. Reproducibility of 11C-raclopride binding in brains of 6 adult rats. •, Mean ROI value in striatum in 6 rats. , Mean ROI value in cerebellum of 6 rats. Error bars are ±1 SD of mean. %ID/cm3 = percentage of injected dose per cubic centimeter.

View larger version (14K): [in a new window]   FIGURE 4. Effect of raclopride mass on DVR. Receptor occupancy is calculated from injected raclopride mass associated with tracer 11C-raclopride according to Hume et al. (23).