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Murine S Factors for Liver, Spleen, and Kidney

¹ Imaging and Spectroscopic Physics Service, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York

View larger version (32K): [in a new window]   FIGURE 1. Three-panel composite image from dose histogram displays module of 3D-ID. (A) Transverse slice of mouse MR image with contours shown for spleen (green), right kidney (yellow), left kidney (red), and liver (orange). (B and C) Corresponding transverse slices from ß-dose distribution images of 131I and 90Y, respectively. Also shown in panels B and C are isodose curves at 1%, 5%, 50%, and 90% levels. Bulge in 1% isodose level shows effect from 0.5-mm-distant portions of spleen. However, as seen in 131I image, even 1% level does not irradiate nearest organ (left kidney) compared with 90Y image, which shows significant portion of left kidney receiving dose from spleen at 1% isodose level.

View larger version (13K): [in a new window]   FIGURE 2. Dose volume histogram of liver to right kidney for 131I (light line) and 90Y (heavy line). It can be observed in dose volume histogram that ß-dose effect of 90Y extends over longer range.

View larger version (14K): [in a new window]   FIGURE 3. Comparison of ß S factor values in spheres of different masses calculated using different methods. S factors derived from 3D-ID calculations are denoted by circular symbols and are compared with Bardies and Chatal (26), denoted by square symbols, and Siegal and Stabin (27), indicated by triangular symbols. Top graph, indicated by dashed line and unfilled symbols, plots S factor values for 90Y, whereas lower graph, indicated by solid line and solid symbols, plots S factors value comparisons for 131I. It can be seen in graph that values generally fall on same line, with best coincidence seen in middle of graph and less coincidence seen on either end. Sphere of smallest radii shows most disparity of values as calculated by 3 methods.