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The Effect of Nitroglycerin on Myocardial Blood Flow in Various Segments Characterized by Rest-Redistribution Thallium SPECT

Eiji Tadamura, MD, PhD1, Marcelo Mamede, MD1, Shigeto Kubo, MD1, Hiroshi Toyoda, MD, PhD1, Masaki Yamamuro, MD1, Hidehiro Iida, PhD2, Nagara Tamaki, MD, PhD3, Kazunobu Nishimura, MD, PhD4, Masashi Komeda, MD, PhD4 and Junji Konishi, MD, PhD1

1 Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, Kyoto, Japan
2 Department of Investigative Radiology, National Cardiovascular Center, Suita, Japan
3 Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan
4 Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan



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  		FIGURE 1. Schematic presentation of ROI definition. Twelve ROIs were determined in the 3 short-axis slices.

 


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  		FIGURE 2. MBF at rest and after NTG, compared with rest-redistribution 201Tl SPECT findings.

 


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  		FIGURE 3. CVR at rest and after NTG, compared with rest-redistribution 201Tl SPECT findings.

 


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  		FIGURE 4. Short-axis images of rest and redistribution 201Tl SPECT for patient who shows reversible perfusion defects in anterior and septal regions. In midventricular septum, CVR decreased after NTG spray from 151 to 126 mm Hg/(mL/min/g), whereas CVR did not significantly change in lateral wall with normal 201Tl activity (130 vs. 132 mm Hg/[mL/min/g]).

 




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