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18F-FDG PET for the Diagnosis and Grading of Soft-Tissue Sarcoma: A Meta-Analysis

John P.A. Ioannidis, MD1,2 and Joseph Lau, MD1

1 Tufts–New England Medical Center Evidence-Based Practice Center, Division of Clinical Care Research, Department of Medicine, Tufts–New England Medical Center, Boston, Massachusetts
2 Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece



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  		FIGURE 1. SROC curves for (A) qualitative visualization, (B) standard uptake value (cutoff, 2.0), (C) standard uptake value (cutoff, 3.0), and (D) metabolic rate of glucose (cutoff, 6.0 µmol/100 g/min). Curves show trade-off between true-positive rate (sensitivity) and false-positive rate (100 - specificity) across all pertinent studies. Each study is shown by eclipse with diameters approximately proportional to number of subjects evaluated for sensitivity (vertical dimension) and specificity (horizontal dimension) of study. Two SROC curves are shown based on weighted (bold line) and unweighted (thin line) calculations. SROC curves should be used for inferences of diagnostic accuracy preferably within range of sensitivity and specificity values of studies that are included in their calculations. X = random effects estimates of sensitivity and specificity; horizontal and vertical dimensions of rectangle = corresponding 95% confidence intervals.

 




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