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An Intrapatient Comparison of ^99mTc-EDDA/HYNIC-TOC with ¹¹¹In-DTPA-Octreotide for Diagnosis of Somatostatin Receptor-Expressing Tumors

¹ Department of Nuclear Medicine, University of Innsbruck, Innsbruck, Austria
² Institute of Biostatistics, University of Innsbruck, Innsbruck, Austria
³ Nuclear Medicine Research Laboratory, St. Bartholomew’s Hospital, London, United Kingdom

View larger version (28K): [in a new window]   FIGURE 1. Number of abnormal findings revealed by 99mTc-TOC and 111In-OCT in 31 patients.

View larger version (85K): [in a new window]   FIGURE 2. A 51-y-old man (patient 23) with multiple liver metastases of small bowel carcinoid. Matching tracer accumulations are shown by 99mTc-TOC and 111In-OCT on anterior views (99mTc-TOC 4 h after injection [A] and 111In-OCT 24 h after injection [B]) as well as on SPECT (99mTc-TOC 4 h after injection [C] and 111In-OCT 24 h after injection [D]).

View larger version (159K): [in a new window]   FIGURE 3. A 66-y-old woman (patient 14) with papillary thyroid cancer. SSTR scintigraphy with 99mTc-TOC (A) shows clear uptake in solitary metastasis in right lung. 111In-OCT scan was negative 4 and 24 h after injection (B).

View larger version (97K): [in a new window]   FIGURE 4. A 69-y-old woman (patient 34) monitored 2 y after surgical treatment of small bowel carcinoid. On 99mTc-TOC scan, focal uptake (A), highly suspicious for tumor recurrence, was observed in abdomen (arrow). 111In-OCT images were negative at 4 h (B) and 24 h (C) after injection. Further investigations could not confirm this abnormal finding; 99mTc-TOC scan result was considered false.

View larger version (29K): [in a new window]   FIGURE 5. Statistical analysis of tumor-to-organ ratios in matching studies with pathologic uptake (n = 21).