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Evaluation of 111In-DTPA-Folate as a Receptor-Targeted Diagnostic Agent for Ovarian Cancer: Initial Clinical Results

Barry A. Siegel, MD1,2, Farrokh Dehdashti, MD1,2, David G. Mutch, MD2,3, Donald A. Podoloff, MD4, Richard Wendt, PhD4, Gregory P. Sutton, MD5, Robert W. Burt, MD6, P. Ron Ellis, MBA7, Carla J. Mathias, BA8, Mark A. Green, PhD8 and David M. Gershenson, MD9

1 Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
2 Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri
3 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
4 Department of Nuclear Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas
5 Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana
6 Department of Radiology, Veterans Affairs Medical Center, Indianapolis, Indiana
7 Endocyte, Inc., West Lafayette, Indiana
8 Division of Nuclear Pharmacy, Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana
9 Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas



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  		FIGURE 1. Structural formula of 111In-DTPA-folate.

 


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  		FIGURE 2. Anterior and posterior planar scintigrams obtained 4 h after administration of 111In-DTPA-folate. The 2 leftmost images, of patient 15, demonstrate increased tracer uptake (arrow) corresponding to solid tumor component in rim of poorly differentiated adenocarcinoma of left ovary. The 2 rightmost images, of patient 9, show region of focally decreased activity (arrow) corresponding to simple serous benign cyst. (Foci of increased activity between legs of each patient are reference sources used for dosimetry calculations.)

 




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