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Tracer Adenosine: A Novel Myocardial Flow Marker

¹ Klinik für Kardiologie, Pneumologie und Angiologie, Heinrich-Heine-Universität, Düsseldorf, Germany
² Institut für Haemostaseologie und Transfusionsmedizin, Heinrich-Heine-Universität, Düsseldorf, Germany
³ Institut für Physiologie, Medizinische Fakultät, TU Dresden, Dresden, Germany

View larger version (20K): [in a new window]   FIGURE 1. Aortic indicator dilution curves of 3H-adenosine and tracer microspheres under control conditions. Percentage fractions of respective tracers in whole blood emerging into aorta within 5 min after start of tracer application through left atrium are depicted for representative experiment. Linear scaling (A) and logarithmic scaling (B) of y-axis panel facilitate comparison between tracers at early and late times.

View larger version (24K): [in a new window]   FIGURE 2. Relationship between relative deposition densities of coinjected tracer microspheres and 3H-adenosine in left ventricular free wall during either control conditions, EHNA infusion, or alprostadil infusion. To facilitate comparison of different experiments, absolute flow values were normalized with respect to average deposition densities. Linear regression analysis was performed for all data points (solid line). Dotted line is line of identity.

View larger version (17K): [in a new window]   FIGURE 3. Relationship between relative deposition densities of coinjected 3H-adenosine and 14C-adenosine in left ventricular free wall. Data are normalized with respect to average deposition density. Solid line is linear regression line. Dotted line is line of identity.

View larger version (38K): [in a new window]   FIGURE 4. Maps of local deposition densities of 3H-adenosine (n = 120) in left ventricular free wall during intracoronary alprostadil infusion. (A) Scheme of sample preparation. (B) Sample groups along base to apex axis represent 5 slices from left ventricular free wall starting with slice 1 on left (base) to slice 5 on right (apex). Each slice contains data from 6 sectors starting with sector 1 (bottom) and ending with sector 6 (top). Four layers of myocardium are ordered from inner (subendocardium) to outer (subepicardium). Data are from experiment 7. Subend = subendocardium; subep = subepicardium.