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Rapid and Specific Targeting of ¹²⁵I-Labeled B Lymphocyte Stimulator to Lymphoid Tissues and B Cell Tumors in Mice

¹ Preclinical Development, Human Genome Sciences, Incorporated, Rockville, Maryland
² Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee

View larger version (23K): [in a new window]   FIGURE 1. %ID/g after intravenous injection of 50 µg/kg of 125I-BLyS into normal BALB/c mice. Female BALB/c mice were injected intravenously with 125I-BLyS at 50 µg/kg, and biodistribution was determined by the tissue dissection method at 1, 3, 6, 16, and 24 h after injection. Error bars represent SEM.

View larger version (34K): [in a new window]   FIGURE 2. QWBA after intravenous injection of 50 µg/kg of 125I-BLyS into normal BALB/c mice. Female BALB/c mice were injected intravenously with 125I-BLyS at 50 µg/kg and were frozen for QWBA at 1, 3, 6, 16, and 24 h after injection. Images were contrast-enhanced for display purposes only. GALT = gut-associated lymphoid tissue.

View larger version (19K): [in a new window]   FIGURE 3. %ID/g after intravenous injection of 50 µg/kg of 125I-BLyS into BCL1 tumor-bearing BALB/c mice. BCL1 tumor-bearing female BALB/c mice were injected intravenously with 125I-BLyS at 50 µg/kg, and biodistribution was determined by tissue dissection method at 1, 3, 6, 16, and 24 h after injection. Error bars represent SEM.

View larger version (35K): [in a new window]   FIGURE 4. QWBA after intravenous injection of 50 µg/kg of 125I-BLyS into BCL1 tumor-bearing BALB/c mice. BCL1 tumor-bearing female BALB/c mice were injected intravenously with 125I-BLyS at 50 µg/kg and were frozen for QWBA at 1, 3, 6, 16, and 24 h after injection. Images were contrast-enhanced for display purposes only. GALT = gut-associated lymphoid tissue.

View larger version (21K): [in a new window]   FIGURE 5. %ID/g after intravenous injection of 50 µg/kg of 125I-BLyS into J558 tumor-bearing BALB/c mice. J558 tumor-bearing female BALB/c mice were injected intravenously with 125I-BLyS at 50 µg/kg, and biodistribution was determined by tissue dissection at 6 and 24 h after injection. Error bars represent SEM.

View larger version (43K): [in a new window]   FIGURE 6. QWBA after intravenous injection of 50 µg/kg of 125I-BLyS into J558 tumor-bearing BALB/c mice. J558 tumor-bearing female BALB/c mice were injected intravenously with 125I-BLyS at 50 µg/kg and were frozen for QWBA at 6 and 24 h after injection. Two cross-sections taken at different depths from same animal are shown for each time point to illustrate distribution both at level of subcutaneous tumor and at level of most major organs. Images were contrast-enhanced for display purposes only. GALT = gut-associated lymphoid tissue.