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Simple Analytic Method of ¹¹C-Flumazenil Metabolite in Blood

¹ Photon Medical Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
² Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³ Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴ Division of Medical Imaging, Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan
⁵ Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

View larger version (21K): [in a new window]   FIGURE 1. Correlation of percentage of unchanged 11C-FMZ fraction between TLC method and extraction method using plasma samples. Linear regression curve shows y = 0.99x + 0.18. Correlation efficient estimated by Pearson correlation analysis is 0.995.

View larger version (17K): [in a new window]   FIGURE 2. Typical time-activity curves after injection of 11C-FMZ. (A) Time-activity curve obtained using whole blood samples and extraction method. +, Radioactivity in whole blood samples (kBq/mL); , unmetabolized 11C-FMZ in whole blood samples (kBq/mL). (B) Time-activity curve obtained using plasma samples and extraction method. x, Radioactivity in plasma samples (kBq/mL); , unmetabolized 11C-FMZ in plasma samples (kBq/mL).

View larger version (18K): [in a new window]   FIGURE 3. Time course of percentage of unchanged 11C-FMZ fraction of all subjects. , Time course of percentage of unchanged 11C-FMZ fraction obtained from whole blood extraction method; , time course of percentage of unchanged 11C-FMZ fraction obtained from plasma extraction method. Data are presented as mean ± SD.