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Long-Term Effects of "Ecstasy" Use on Serotonin Transporters of the Brain Investigated by PET

¹ Department of Nuclear Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany
² Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

View larger version (66K): [in a new window]   FIGURE 1. Definition of VOIs for putamen, caudate, thalamus, and white matter (left), mesencephalon (middle), and cerebellum (right) in transversal slices of the 11C-(+)-McN5652-PET template. VOIs were composed of circles of 4.1-mm radius drawn in appropriate number of slices (mesencephalon, no. of slices = 3/no. of circles = 9/no. of voxels = 50; putamen, 4/24/166; caudate, 6/12/83; thalamus, 4/16/105; cerebellum, 5/40/273; white matter, 8/16/108).

View larger version (10K): [in a new window]   FIGURE 2. Representative time-activity curves. SUVs for mesencephalon, thalamus, white matter, and cerebellum VOIs in drug-naive control subject are plotted.