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Decreased 5-HT_2a Receptor Binding in Patients with Anorexia Nervosa

¹ Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
² Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
³ Department of Radiopharmacy, Ghent University, Ghent, Belgium
⁴ VUB-Cyclotron, Brussels, Belgium

View larger version (67K): [in a new window]   FIGURE 1. Transaxial, coronal, and sagittal representations of volume-of-interest (VOI) region map oriented in Talairach space as used for study. VOIs represent specific Brodmann’s areas and are shown in different colors. Because of low degrees of freedom, frontal, temporal, parietal, and occipital VOIs were grouped for analysis (Table 1).

View larger version (101K): [in a new window]   FIGURE 2. Example of 25-y-old patient with AN compared with anatomically standardized control population for this study.

View larger version (20K): [in a new window]   FIGURE 3. Plot of individual binding index values in healthy volunteers and patients with AN. Male volunteers are indicated with arrow.