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Bicycle Exercise Stress in PET for Assessment of Coronary Flow Reserve: Repeatability and Comparison with Adenosine Stress

¹ Nuclear Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
² Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Zurich, Switzerland

View larger version (19K): [in a new window]   FIGURE 1. MBF was assessed with H215O and PET at rest (Rest 1), during adenosine-induced hyperemia (Ado 1; intravenous adenosine infusion at 140 µg/min/kg over 7 min), and immediately after supine bicycle exercise (Ex 1) in scanner (workload is indicated in watts). All measurements were repeated (Rest 2, Ado 2, and Ex 2) after 20-min transmission scan.

View larger version (24K): [in a new window]   FIGURE 2. (A) Repeated resting and hyperemic MBF measurements. Paired values are given for each participant. Mean values (large circles) are given as mean ± 1 SD. (B) Differences in paired values are plotted against their average value (Bland-Altman plot). Repeatability is best at rest but comparable during adenosine and bicycle exercise. Rest 1 and 2, Ado 1 and 2, and Ex 1 and 2 are defined as in Figure 1.

View larger version (13K): [in a new window]   FIGURE 3. Scattergram of repeated MBF measurements (mL/min/g). Line of equality, along which points would lie if agreement were perfect, is shown.

View larger version (26K): [in a new window]   FIGURE 4. (A) Repeated assessment of CFR with and without correction of baseline MBF for RPP. Paired values are given for each participant. Mean values (large circles) are given as mean ± 1 SD. (B) Differences in paired values are plotted against their average value (Bland-Altman plot). Ado 1 and 2 and Ex 1 and 2 are defined as in Figure 1; corr = corrected.

View larger version (15K): [in a new window]   FIGURE 5. Scattergram of repeated CFR measurements (relative values). Line of equality, along which points would lie if agreement were perfect, is shown.