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Lipiodol Solution of 188Re-HDD as a New Therapeutic Agent for Transhepatic Arterial Embolization in Liver Cancer: Preclinical Study in a Rabbit Liver Cancer Model

Jin Chul Paeng, MD1, Jae Min Jeong, PhD1,2,3, Chang Jin Yoon, MD4, Yun-Sang Lee, MS1,3,5, Young-Ger Suh, PhD5, Jin Wook Chung, MD4, Jae Hyung Park, MD4, June-Key Chung, MD1,2, Miwon Son, PhD6 and Myung Chul Lee, MD1,3

1 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
2 Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
3 Clinical Research Institute, Seoul National University College of Medicine, Seoul, Korea
4 Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
5 Seoul National University College of Pharmacy, Seoul, Korea
6 Dong-A Pharmaceutical Co., Seoul, Korea



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  		FIGURE 1. Molecular formulas of 188Re-TDD and 188Re-HDD. TDD is derivative of N2S2 compound, and its 188Re chelate is highly lipophilic. 188Re chelate of HDD has higher lipophilicity because of presence of long alkyl chain.

 


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  		FIGURE 2. Rabbits with TAE. (A) ROIs were drawn for whole body and tumor in rabbits of each group. (B) In CT (top) and SPECT (bottom) images, lipiodol (white arrow) and matching radioactivity (black arrow) were effectively localized and visualized in hepatic tumors.

 


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  		FIGURE 3. Dynamic images of 188Re-HDD/lipiodol and 188Re-TDD/lipiodol. 188Re-HDD shows significantly longer retention in tumor (arrow) until 48 h than does 188Re-TDD. 188Re-TDD was excreted to gut faster than was 188Re-HDD.

 


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  		FIGURE 4. Time-activity curve of ROIs around hepatic tumors for 188Re-TDD/lipiodol and 188Re-HDD/lipiodol treatment. Half-life and residence time of 188Re-HDD/lipiodol were significantly longer than those of 188Re-TDD/lipiodol.

 




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