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When May a Nonuniform Distribution of ¹³¹I Be Considered Uniform? An Experimental Basis for Multicellular Dosimetry

¹ Division of Radiation Research, Department of Radiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey

View larger version (21K): [in a new window]   FIGURE 1. Assembly of multicellular cluster of V79 cells wherein 10% cells were radiolabeled with 131IdU.

View larger version (23K): [in a new window]   FIGURE 2. Dependence of cellular uptake of 131I on initial extracellular concentration of 131IdU in culture medium. Different symbols correspond to data collected during experiments involving 100% (), 10% (), or 1% () labeling. In 100% case, 4 x 106 cells were labeled, whereas 4 x 105 cells were labeled to prepare 10% and 1% (only 4 x 104 cells were used) cases. Linear least-squares fit of data is also shown for each case: 100% (thin line), 10% (dashed line), 1% (bold line). Inset shows enlargement of 100% case.

View larger version (23K): [in a new window]   FIGURE 3. Survival of V79 cells in multicellular clusters as function of initial 131I activity per labeled cell. Data are shown for experiments where 100% (), 10% (), or 1% () of cells in multicellular cluster were labeled with 131IdU. Clusters were maintained at 10.5°C for 72 h and then survival fraction was determined compared with that of cells from control clusters (0% labeled). Data from 3 independent experiments are plotted for each labeling condition. Least-squares fits of data are shown for each labeling condition.

View larger version (19K): [in a new window]   FIGURE 4. Survival of V79 cells in multicellular clusters as function of initial 131I activity per cluster. Data are shown for experiments where 100% (), 10% (), or 1% () of cells in multicellular cluster were labeled with 131IdU. Clusters were maintained at 10.5°C for 72 h and then survival fraction was determined compared with that of cells from control clusters (0% labeled). Least-squares fits of data corresponding to each labeling condition are shown: 100% (thin line), 10% (dashed line), 1% (bold line).

View larger version (16K): [in a new window]   FIGURE 5. Survival of V79 cells after chronic irradiation of multicellular clusters with 137Cs -rays. All irradiations were performed at 10.5°C over 72-h period. Data from 3 independent experiments are shown (•, , ); represents data reported earlier (26). Additional data was acquired to define survival curve at low survival fractions and thereby allow comparison between 137Cs and 131IdU dose-response curves. Dotted curve represents least-squares fit of 137Cs data to linear quadratic model. For comparison, least-squares fits of 131IdU data (survival fraction vs. mean absorbed dose to cluster) to 2-component exponential function are also shown for 3 labeling conditions: 100% (thin line), 10% (dashed line), 1% (bold line).