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Shortened PET Data Acquisition Protocol for the Quantification of 18F-FDG Kinetics

Ludwig G. Strauss, MD, Antonia Dimitrakopoulou-Strauss, MD and Uwe Haberkorn, MD

Medical PET Group, Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany



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  		FIGURE 1. Correlation of 18F-FDG influx as calculated by 2-compartment model (influx [observed]) and predicted influx (influx [predicted]) using short acquisition protocol. Dynamic input data from 1 to 10 min (10 frames) and target area from 1 to 10 min (10 frames) and from 56 to 60 min (1 frame) were used for prediction, based on polynomial function (degree 2) for data fitting. Correlation coefficient of 0.9028 was obtained.

 


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  		FIGURE 2. Correlation of VB as calculated by 2-compartment model (VB [observed) and predicted VB (VB [predicted]) using short acquisition protocol. Input data from 1 to 10 min (10 frames) and target area from 1 to 10 min (10 frames) and from 56 to 60 min (1 frame) were used for prediction, based on polynomial function (degree 2) for data fitting. Correlation coefficient of 0.9195 was obtained.

 


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  		FIGURE 3. Correlation of k1 as calculated by 2-compartment model (k1 [observed) and predicted k1 (k1 [predicted]) using short acquisition protocol. Input data from 1 to 10 min (10 frames) and target area from 1 to 10 min (10 frames) and from 56 to 60 min (1 frame) were used for prediction, based on polynomial function (degree 2) for data fitting. Correlation coefficient of 0.9305 was obtained.

 




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