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N,N-Dimethyl-2-(2-Amino-4-¹⁸F-Fluorophenylthio)-Benzylamine (4-¹⁸F-ADAM): An Improved PET Radioligand for Serotonin Transporters

¹ Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
² Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
³ Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania

View larger version (14K): [in a new window]   FIGURE 1. Chemical structures of (+)McN5652, 403U76, IDAM, ADAM, DASB, AFM, DAPA, MADAM, and 4-F-ADAM.

View larger version (100K): [in a new window]   FIGURE 2. PET images of 4-18F-ADAM in baboon brain and MR images of baboon brain at same level as PET images. PET scan displays specific binding of 4-18F-ADAM to SERT in midbrain region at 90–120 min after radioligand injection. MRI scan reveals anatomic information about midbrain region.

View larger version (18K): [in a new window]   FIGURE 3. Time–activity curve of 4-18F-ADAM in baboon brain. Curve shows that uptake of 4-18F-ADAM in midbrain region peaks at 30–40 min after injection and that defluorination of 4-18F-ADAM may not occur in baboon.

View larger version (15K): [in a new window]   FIGURE 4. Ratio of different brain regions to cerebellum increases with time in baboon brain after injection of 4-18F-ADAM.