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In Vivo Evidence of Endothelial Injury in Chronic Obstructive Pulmonary Disease by Lung Scintigraphic Assessment of ¹²³I-Metaiodobenzylguanidine

¹ First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
² Department of Laboratory Medicine, Yamagata University School of Medicine, Yamagata, Japan
³ Department of Radiology, Yamagata University School of Medicine, Yamagata, Japan

View larger version (168K): [in a new window]   FIGURE 1. Anterior planar images of lung 123I-MIBG scintigraphy (left, early images; right, delayed images) in representative control subject (Top) and COPD patient (Bottom). M, rt L, and lt L represent counts in ROIs at mediastinum, right lung, and left lung; E and D indicate early images (at 30 min after intravenous injection of 123I-MIBG) and delayed images (at 270 min after intravenous injection of 123I-MIBG), respectively. Note that rt LE, rt LD, lt LE, and lt LD, as well as washout rate (WR) between early and delayed images, are lower in COPD patient than in control subject.

View larger version (18K): [in a new window]   FIGURE 2. Relationship between % FEV1.0 and lung WR of 123I-MIBG (%) in study population. There is significant positive correlation between them (r = 0.386, P < 0.05). •, COPD patients; , control subjects.

View larger version (20K): [in a new window]   FIGURE 3. Relationship between DLCO/VA (mL/min/mm Hg/L) and lung WR of 123I-MIBG (%) in study population. There is significant positive correlation between them (r = 0.449, P < 0.01). •, COPD patients; , control subjects.

View larger version (18K): [in a new window]   FIGURE 4. Relationship between PaO2 (mm Hg) and lung WR of 123I-MIBG (%) in study population. There is significant positive correlation between them (r = 0.474, P < 0.01). •, COPD patients; , control subjects.

View larger version (18K): [in a new window]   FIGURE 5. Relationship between [A-a]DO2 (mm Hg) and lung WR of 123I-MIBG (%) in study population. There is significant inverse correlation between them (r = -0.446, P < 0.01). •, COPD patients; , control subjects.

View larger version (18K): [in a new window]   FIGURE 6. Relationship between % LAA and lung WR of 123I-MIBG (%) in study population. There is significant inverse correlation between them (r = -0.458, P < 0.01). •, COPD patients; , control subjects.