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Quantitative Gated PET for the Assessment of Left Ventricular Function in Small Animals

¹ Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, Québec, Canada; and the Metabolic and Functional Imaging Center, Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada

View larger version (38K): [in a new window]   FIGURE 1. Schematic of heart phantom showing variable-volume internal chamber filled with water and sealed, fixed-volume dual-layer wall filled with 18F-FDG. Phantom can accommodate endocardial volume ranging from 150 to 1,000 µL. Shown on right is example of systolic (300 µL) and diastolic (900 µL) images extracted by QGS analysis of simulated series of gated PET images of phantom. SA = short axis; HLA = horizontal long axis; VLA = vertical long axis.

View larger version (72K): [in a new window]   FIGURE 2. Results of QGS-analyzed, ECG-gated 18F-FDG PET of normal and infarcted rats using Sherbrooke small-animal PET scanner. EF = ejection fraction.

View larger version (15K): [in a new window]   FIGURE 3. Correlation between endocardial volume of cardiac phantom and volume determined using QGS: linear regression analysis of measurements performed in triplicate (A) and Bland–Altman plot (B). Sy.x = SEE.

View larger version (14K): [in a new window]   FIGURE 4. Correlation between ventricular end-systolic and end-diastolic volumes measured by gated PET and echocardiography in healthy rats (n = 11): linear regression (A) and Bland–Altman plot (B). Echo = echocardiography; Sy.x = SEE.

View larger version (15K): [in a new window]   FIGURE 5. Correlation between ventricular end-systolic and end-diastolic volumes measured by gated PET and echocardiography in infarcted (n = 15) and septic (n = 4) rats: linear regression (A) and Bland–Altman plot (B). Echo = echocardiography; Sy.x = SEE.

View larger version (15K): [in a new window]   FIGURE 6. Correlation between LVEF measured by gated PET and echocardiography for normal (n = 11), infarcted (n = 15), and septic (n = 4) rats: linear regression (A) and Bland–Altman plot (B). Echo = echocardiography; Sy.x = SEE.