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Preliminary Evaluation of a Fuzzy Logic-Based Automatic Quantitative Analysis in Myocardial SPECT

¹ Division of Nuclear Medicine, Jean Perrin Cancer Center, Clermont-Ferrand, France
² Department of Cardiology, Gabriel Montpied University Hospital, Clermont-Ferrand, France

View larger version (32K): [in a new window]   FIGURE 1. Activity profile (dashed line) and profile of corresponding degree of belonging (bold line) along vertical line in midportion of vertical long-axis section. Profiles were obtained from original SPECT image (left) and calculated image of degree of belonging (right), respectively. Large inferior defect seen on SPECT image disappears on functional image.

View larger version (7K): [in a new window]   FIGURE 2. Example of different steps of processing (left to right): original SPECT vertical long-axis section in patient with inferior infarction, binary thresholded image and its derived skeleton, completed skeleton, functional image of degree of belonging, and binary image completed with thresholded functional image.

View larger version (21K): [in a new window]   FIGURE 3. Organization of 18 sectors dividing LV wall in small elements of similar volume.

View larger version (73K): [in a new window]   FIGURE 4. Final screen display of Myoflex program shows for each sector mean activity and SD (table in top, circles in bottom) and corrected slices (middle).

View larger version (14K): [in a new window]   FIGURE 5. Correspondence between sectors and coronary artery. NA = not attributed.

View larger version (22K): [in a new window]   FIGURE 6. Intraobserver reproducibility of mean activity determined from 414 sectors of 23 patients with known coronary artery disease (top, linear regression analysis; bottom, Bland-Altman plot).

View larger version (22K): [in a new window]   FIGURE 7. Interobserver reproducibility of mean activity determined from 882 sectors of 49 patients with known coronary artery disease (top, linear regression analysis; bottom, Bland-Altman plot).

View larger version (19K): [in a new window]   FIGURE 8. Sensitivity and specificity of myocardium rest SPECT quantification images for identification of disease in individual coronary arteries.