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Correlation Between Cardiac Norepinephrine Overflow During Exercise and Cardiac 123I-MIBG Uptake in Patients with Chronic Heart Failure

Masahiko Sato, MD, Kazuhira Maehara, MD, Hiroyuki Yaoita, MD, Hiroshi Otani, MD, Akira Hirosaka, MD, Tomiyoshi Saito, MD, Norio Onuki, MD, Nobuo Komatsu, MD, Takako Ishihata, MD and Yukio Maruyama, MD

First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan



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  		FIGURE 1. (A) Changes in NE concentrations at coronary sinus (CS) and brachial artery (artery) with respect to VO2 during graded exercise in representative case with positive NE overflow. (B) Changes of difference in NE concentration between coronary sinus and arterial blood (NECS-A) with respect to VO2. (C) Changes in NECS-A with respect to arterial NE concentration (NEA). (D and E) Initial (D) and delayed (E) 123I-MIBG planar images in anterior view. Cardiac 123I-MIBG activity was reduced only mildly. H/M = 123I-MIBG uptake ratio.

 


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  		FIGURE 2. (A) Changes in NE concentrations at coronary sinus (CS) and brachial artery (artery) with respect to VO2 during graded exercise in representative case with negative NE overflow. (B) Changes of NECS-A with respect to VO2. (C) Changes in NECS-A with respect to arterial NE concentration (NEA). (D and E) Initial (D) and delayed (E) 123I-MIBG planar images in anterior view. Cardiac 123I-MIBG activity was barely recognized. H/M = 123I-MIBG uptake ratio.

 


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  		FIGURE 3. Scatter diagram illustrating relationship between H/M of delayed image and NECS-A at peak exercise. There was positive linear relationship between them (r = 0.80, P < 0.01).

 




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