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Efficacy of Carvedilol Treatment on Cardiac Function and Cardiac Sympathetic Nerve Activity in Patients with Dilated Cardiomyopathy: Comparison with Metoprolol Therapy

Takuji Toyama, MD, Hiroshi Hoshizaki, MD, Ryotaro Seki, MD, Naoki Isobe, MD, Hitoshi Adachi, MD, Shigeto Naito, MD, Shigeru Oshima, MD and Koichi Taniguchi, MD

Gunma Prefectural Cardiovascular Center, Maebashi, Japan



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  		FIGURE 1. Diagram of segmentation scheme used to assess regional 123I-MIBG and 99mTc-MIBI uptake.

 


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  		FIGURE 2. Correlation between change in LVEF and TDS. There were mild correlations in patients receiving metoprolol (r = 0.53) and carvedilol (r = 0.41). {circ}, Patients receiving metoprolol; •, patients receiving carvedilol.

 


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  		FIGURE 3. Relationship between change in LVEF and H/M. There were no significant relationships in patients receiving metoprolol and carvedilol. {circ}, Patients receiving metoprolol; •, patients receiving carvedilol.

 


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  		FIGURE 4. Comparison between patients with favorable response and without favorable response in TDS. Favorable response means improvement of TDS >=10 after ß-blocker treatments. Improvement of LVEF in patients with favorable response was higher than that in patients without favorable response (P < 0.05).

 


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  		FIGURE 5. Comparison between patients with favorable response and without favorable response in H/M. Favorable response means improvement of H/M >=0.3 after ß-blocker treatments. Improvement of LVEF in patients with favorable response was higher than that in patients without favorable response (P < 0.05).

 


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  		FIGURE 6. Representative case of metoprolol treatment. 123I-MIBG and 99mTc-MIBI images were obtained from short-axis and vertical long-axis reconstructions.

 


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  		FIGURE 7. Representative case of carvedilol treatment. 123I-MIBG and 99mTc-MIBI images were obtained from short-axis and vertical long-axis reconstructions.

 




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