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Detection of Apoptotic Tumor Response In Vivo After a Single Dose of Chemotherapy with ^99mTc-Annexin V

¹ Department of Radiology, Nikko Memorial Hospital, Muroran, Japan
² Department of Tracer Kinetics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
³ Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
⁴ Department of Pathological Oncology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
⁵ Department of Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York
⁶ Division of Nuclear Medicine, Department of Radiology, Stanford University School of Medicine, Stanford, California
⁷ Department of Laboratory Medicine, University of Washington, Seattle, Washington

View larger version (17K): [in a new window]   FIGURE 1. Uptake of 99mTc-annexin V (A) and number of TUNEL-positive cells (B) in tumor. Uptake of 99mTc-annexin V and number of TUNEL-positive cells were significantly higher in treated tumor than in control tumor. Control = control rats; treated = rats treated with cyclophosphamide (150 mg/kg intraperitoneally).

View larger version (149K): [in a new window]   FIGURE 2. TUNEL staining (x200) of tumor specimens in control rats (A) and treated rats (B). Cells stained brown were considered TUNEL positive. TUNEL-positive cells were observed in tumor specimens obtained from both control and treated rats.

View larger version (17K): [in a new window]   FIGURE 3. Correlation of uptake of 99mTc-annexin V and number of TUNEL-positive cells in tumor. Tumor uptake of 99mTc-annexin V significantly correlated with number of TUNEL-positive cells in tumor. (Uptake of 99mTc-annexin V) = 0.025 + 1.397 x 10-4 x (number of TUNEL-positive cells); r = 0.712; P < 0.001. = control rats; = treated rats.