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Comparison of Microsphere-Equivalent Blood Flow (¹⁵O-Water PET) and Relative Perfusion (^99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch

¹ Department of Nuclear Medicine, University Hospital, Aachen University of Technology, Aachen, Germany
² Department of Internal Medicine I (Cardiology), University Hospital, Aachen University of Technology, Aachen, Germany

View larger version (19K): [in a new window]   FIGURE 1. Definition of 18 myocardial tissue ROIs on 3 representative short-axis slices (apex, midventricular, and base). Left ventricular input (LV-Inp.) ROI is located in basal slice.

View larger version (16K): [in a new window]   FIGURE 2. (A) ROIs with increased volumes but all containing approximately same myocardial mass. (B) ROI volume dependencies of MBF_kin, 99mTc-tetrofosmin uptake, MBF_micr, tissue fraction, and 18F-FDG uptake. All values are expressed as ratios of respective value with A (smallest ROI).

View larger version (58K): [in a new window]   FIGURE 3. Mean MBF_micr (mL·min-1· mL-1) and relative 99mTc-tetrofosmin uptake of investigated 6 segments and of all segments classified as normal (abscissa). 99mTc-tetrofosmin uptake values are normalized to respective patient’s maximum uptake region, set as 100%. Ant = anterior; lat = lateral; post = posterior; seg. = segments; sep = septal.

View larger version (40K): [in a new window]   FIGURE 4. Mean MBF_micr (mL·min-1·mL-1) and relative 99mTc-tetrofosmin uptake in normal myocardium and MPMM myocardium. 99mTc-tetrofosmin uptake values are normalized to respective patient’s maximum uptake region, set as 100%. n. s. = not statistically significant.

View larger version (58K): [in a new window]   FIGURE 5. Segmental MPMM-to-normal percentages of mean MBF_micr and relative 99mTc-tetrofosmin uptake. Mean normal values are set as 100% for each segment for either parameter. n = number of MPMM segments. *P < 0.05. ***P < 0.005. Ant = anterior; lat = lateral; post = posterior; sep = septal.