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Dipyridamole, Cold Pressor Test, and Demonstration of Endothelial Dysfunction: A PET Study of Myocardial Perfusion in Diabetes

¹ Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
² Steno Diabetes Center, Gentofte, Denmark

View larger version (15K): [in a new window]   FIGURE 1. CBF values at rest, during CPT, and after dipyridamole (DIPY) during saline infusion (A) or perindoprilat (ACE inhibitor) infusion (B). Values are mean ± SEM for 10 subjects (5 for ACE inhibitor control subjects). *P < 0.05 vs. control subjects. #P < 0.05 vs. NIDDM patients. ##P < 0.01 vs. rest. White bars = NIDDM patients; black bars = control subjects.

View larger version (17K): [in a new window]   FIGURE 2. Individual CBF responses to CPT in saline-treated (left panels) or perindoprilat-treated (right panels) NIDDM patients (top panels) or control subjects (bottom panels).